Wolfram SystemModeler ships with model libraries for a large selection of domains such as electronics, mechanics, and biochemistry. Now I am pleased to present a new library in the family, the SystemDynamics library by FranG§ois E. Cellier and Stefan Fabricius. System dynamics, a methodology developed by Jay Forrester in the `60s and `70s, is wel
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l suited for understanding the dynamics of large-scale systems with diverse components. It has been famously applied by the Club of Rome to investigate the limits of human growth; other applications include production management, life sciences, and economics (some showcases of the methodology can be found here ). Yesterday, the Nobel Prize in Chemistry was awarded to Robert J. Lefkowitz and Brian K. Kobilka for having mapped how a family of cellular receptors called G-protein-coupled receptors (GPCRs) work. The Nobel Prize winners` research has proven to be very important in the development of novel therapeutic drugs ”about 40 50% of all therapeutic drugs in use today are centered on GPCRs. The real beauty of GPCR-based response systems is that they include components that are used over and over again for the response to external signals in many kinds of cellular functions throughout our bodies. Sight, smell, and the adrenaline response are examples of these GPCR-mediated responses with physiologically important functions. Identifying new targets for therapeutic drug intervention includes analysis of the complex webs of signaling pathways and feedback systems in our cells, extending beyond the first event of a signal connecting with the GPCR on the cell surface, which is non-trivial. Lately the cost-effective practice of using mathematical models as an initial step for finding those elusive new targets, and also as a tool...
This project fits more for custom made battery casing that can have more space to hide things inside. This switch with few alterations can be used for any other project as well but is designed based on e-bike needs! This project use a clever functionality of....
The circuit described here uses ultrasonic oscillations and operates based on the propagation velocity of these oscillations in the air. Thus, we can easily determine the distance of two points if the time within which the wave travels this distance is....
Sometimes the precious metals are hidden too deep and are not detected except with complicated devices. In many cases, however, small pieces of precious metal buried near the surface can be detected by relatively simple means. Everyone is very attractive to....
Many times for various reasons we forget or can not water the plants that we have in our homes. And many humidity sensors units just notify us with a beeping sound or with a flashing light, that the pot needs watering. But what if we are away from home? This....
The principle behind a metal detector is really very simple. Proof of this is the circuit that follows, in which it proves that the construction of a metal detector can be done in the minute, with few components that we find very easily everywhere. With the....
The sub-harmonic bass generator is a sound producing unit for guitars. The sound it produces looks very much like that of the bass guitar. The octave generator is sometimes quite unusual since it does not produce any of the usual ways of coloring the sound,....
In the past the sounding (sea bottom measurement) was done with the "bullet", that is, with a heavy lead object that the seamen plucked into the sea hung from a calibrated rope. As soon as the "bullet" reached the bottom, the depth appeared directly from the....
This Amplifier was designed to have the following specifications: Distortion less than 0.1% at full power of 100W even at 20KHz. Power has to be attributed to an extended bandwidth. The output transistors must be protected against short circuits. The power....
A series of LEDs serve to alert the gardener when plants need water. Using two conventional digital integrated LEDs and a series of LEDs, we make a very useful device for gardening. The device detects the amount of water in the pot and alerts the grower.....
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